Changes for version 0.04 - 2012-08-15

  • Implemented generalized linear models for regression analyses against clinical data
  • Added tools to generate typical visualizations like Kaplan-Meier survival estimates, and mutation status matrices
  • Support for TCGA Mutation Annotation Format (MAF) version 2.3
  • Performance improvements in mutation rate calculations, and more efficient memory usage
  • Added support for wiggle track format files describing coverage, if BAMs are unavailable

Modules

combining probabilities from independent tests of significance into a single aggregate figure
the Path-Scan significance test for mutations in groups of putative cancer genes
apply PathScan test to populations rather than just single individuals

Provides

in lib/Genome/Model/Tools/Music.pm
in lib/Genome/Model/Tools/Music/Base.pm
in lib/Genome/Model/Tools/Music/Bmr.pm
in lib/Genome/Model/Tools/Music/Bmr/Base.pm
in lib/Genome/Model/Tools/Music/Bmr/CalcBmr.pm
in lib/Genome/Model/Tools/Music/Bmr/CalcCovg.pm
in lib/Genome/Model/Tools/Music/Bmr/CalcCovgHelper.pm
in lib/Genome/Model/Tools/Music/Bmr/CalcWigCovg.pm
in lib/Genome/Model/Tools/Music/ClinicalCorrelation.pm
in lib/Genome/Model/Tools/Music/CosmicOmim.pm
in lib/Genome/Model/Tools/Music/Galaxy.pm
in lib/Genome/Model/Tools/Music/MutationRelation.pm
in lib/Genome/Model/Tools/Music/PathScan.pm
in lib/Genome/Model/Tools/Music/Pfam.pm
in lib/Genome/Model/Tools/Music/Play.pm
in lib/Genome/Model/Tools/Music/Plot.pm
in lib/Genome/Model/Tools/Music/Plot/MutationRelation.pm
in lib/Genome/Model/Tools/Music/Proximity.pm
in lib/Genome/Model/Tools/Music/Smg.pm
in lib/Genome/Model/Tools/Music/Survival.pm